• Drug Description: Haegarda
  • Generic Name: C1 Esterase Inhibitor (Human)
  • Brand Name: Haegarda
  • Dosage Form: Subcutaneous Injection
  • Drug Class: C1 Esterase Inhibitor


What is Haegarda?

Haegarda is a medication used for the prevention of hereditary angioedema (HAE) attacks. It contains the active ingredient C1 Esterase Inhibitor (Human), which is a protein that helps regulate the complement system in the body. Haegarda is administered through subcutaneous injections and is prescribed to individuals with HAE to reduce the frequency, severity, and duration of angioedema attacks.

Indications and Uses:

Hereditary Angioedema (HAE) Prophylaxis: Haegarda is used for the routine prevention of angioedema attacks in adults and adolescents with HAE. It helps to maintain C1 esterase inhibitor levels in the body, reducing the likelihood of sudden and severe swelling episodes.

How Does Haegarda Work?

Haegarda works by providing an exogenous C1 esterase inhibitor, a protein that regulates the complement system. In individuals with HAE, there is a deficiency or dysfunction of endogenous C1 esterase inhibitor, leading to uncontrolled activation of the complement system and subsequent angioedema attacks. By administering Haegarda, the levels of functional C1 esterase inhibitors in the body are increased, helping to restore balance and prevent angioedema attacks.

The Benefits of Haegarda:

  • Reduction in Angioedema Attacks: Haegarda has been shown to significantly reduce the frequency, severity, and duration of angioedema attacks in individuals with HAE. This can greatly improve their quality of life and reduce the need for emergency medical interventions.
  • Prophylactic Protection: By regularly administering Haegarda, individuals with HAE can maintain a constant level of C1 esterase inhibitor, providing ongoing protection against angioedema attacks.
  • Subcutaneous Administration: Haegarda is administered through subcutaneous injections, which can be easily self-administered by patients once trained by a healthcare professional. This allows for convenient and flexible dosing in the comfort of your home.

Warnings and Precautions:

  1. Allergies: Inform your healthcare provider if you have any known allergies or sensitivities to C1 esterase inhibitor (human) or any other components of Haegarda.
  2. Infection Risk: As Haegarda is derived from human blood, there is a risk of transmitting infectious agents. However, thorough screening and testing processes are implemented to minimize this risk. Inform your healthcare provider if you have a history of bloodborne infections or if you are at increased risk for infections.
  3. Pregnancy and Breastfeeding: The safety of Haegarda during pregnancy and breastfeeding has not been fully established. Consult your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.
  4. Drug Interactions: Inform your healthcare provider about all the medications you are taking, including prescription, over-the-counter, and herbal supplements, as they may interact with Haegarda.

Before Using Haegarda:

  • Medical History: Discuss your complete medical history, including any past surgeries, medical conditions, or known drug allergies. 
  • Current Medications: Provide a list of all prescription and over-the-counter medications, vitamins, and supplements you are currently taking, as they may interact with Haegarda.

How is Haegarda Administered?

Haegarda is administered through subcutaneous injections, which are typically self-administered by the patient once trained by a healthcare professional. The dosage and administration technique will depend on the individual's specific needs and the prescribed regimen. It is important to follow the instructions provided by your healthcare provider and adhere to the recommended dosing schedule.

Side Effects of Haegarda:

  • Injection Site Reactions: Mild injection site reactions, such as redness, swelling, itching, or pain, may occur. These reactions are usually transient and resolve on their own.
  • Headache: Some individuals may experience headaches as a side effect of Haegarda. These headaches are generally mild and temporary.
  • Nausea: Nausea and stomach discomfort may occur in some individuals after receiving Haegarda injections.

Further Information:

  • Storage: Haegarda should be stored according to the manufacturer's instructions, typically in a refrigerator at a temperature between 2C and 8C (36F and 46F). Do not freeze the medication. Once removed from the refrigerator, Haegarda can be stored at room temperature (up to 25C or 77F) for up to 7 days. 
  • Disposal: Properly dispose of used Haegarda syringes and needles following local regulations or consult with your healthcare provider or pharmacist for guidance on safe disposal methods.
  • Accessibility: Haegarda is available by prescription only and should be obtained from licensed healthcare facilities or pharmacies.
  • Reporting Adverse Effects: If you experience any adverse effects or have concerns about the medication's safety, report them to your healthcare provider or the local regulatory authority.

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