• Generic Name: Pitolisant
  • Brand Name: Wakix
  • Dosage Forms: Oral tablets
  • Drug Class: Histamine H3 receptor antagonist


What is Wakix?

Wakix (pitolisant) is a medication used to treat excessive daytime sleepiness in adult patients with narcolepsy. It is a selective histamine H3 receptor antagonist that works by increasing the release of histamine in the brain, promoting wakefulness, and reducing excessive sleepiness.

Indications and Uses:

Wakix is prescribed for the treatment of excessive daytime sleepiness (EDS) in adult patients with narcolepsy. Narcolepsy is a chronic neurological disorder characterized by overwhelming daytime sleepiness, sudden and uncontrollable episodes of falling asleep, and disrupted sleep patterns.

How Does Wakix Work?

Wakix works by selectively blocking the histamine H3 autoreceptors in the brain. By doing so, it enhances the release of histamine, a neurotransmitter that plays a key role in promoting wakefulness. This mechanism helps to alleviate excessive daytime sleepiness in patients with narcolepsy.

The Benefits of Wakix:

  • Improved Wakefulness: Wakix helps to promote wakefulness and reduce excessive daytime sleepiness, allowing individuals with narcolepsy to stay alert and functional during the day.
  • Enhanced Quality of Life: By reducing the debilitating symptoms of narcolepsy, Wakix can significantly improve the quality of life for patients. It enables them to participate in daily activities, work, and social interactions more effectively.
  • Fewer Cataplexy Episodes: Cataplexy, a sudden loss of muscle tone triggered by emotions, is a common symptom of narcolepsy. Wakix has shown effectiveness in reducing the frequency and severity of cataplexy episodes, providing relief to patients.

Warnings and Precautions:

  • Hypersensitivity: Inform your healthcare provider if you have any known allergies or sensitivities to pitolisant or any other ingredients present in the medication.
  • Liver Impairment: Wakix should be used with caution in patients with liver impairment. Dose adjustments may be necessary to ensure the safe and effective use of the medication.
  • Drug Interactions: Inform your healthcare provider about all the medications you are taking, including prescription, over-the-counter, and herbal supplements, as they may interact with Wakix.
  • Pregnancy and Breastfeeding: The safety of Wakix during pregnancy or breastfeeding has not been established. Consult your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.

Before Using Wakix:

  • Medical History: Discuss your complete medical history, including any past surgeries, medical conditions, or known drug allergies.
  • Current Medications: Provide a list of all prescription and over-the-counter medications, vitamins, and supplements you are currently taking, as they may interact with Wakix.

How is Wakix Administered?

Wakix is taken orally, usually once daily in the morning. The recommended dosage will be determined by your healthcare provider based on your individual needs and response to treatment. It is important to follow the prescribed dosage and instructions for optimal effectiveness.

Side Effects of Wakix:

Like any medication, Wakix can cause side effects. Common side effects may include:

These side effects are usually mild and temporary. However, if they persist or worsen, it is important to contact your healthcare provider for further guidance.

Further Information:

  • Storage: Wakix should be stored at room temperature, away from moisture and heat. Follow the specific storage instructions provided by the manufacturer.
  • Disposal: Properly dispose of any unused or expired Wakix following local regulations or consult with your healthcare provider or pharmacist for guidance on safe disposal methods.
  • Accessibility: Wakix is available by prescription only and should be obtained from licensed healthcare facilities or pharmacies.
  • Reporting Adverse Effects: If you experience any adverse effects or have concerns about the medication's safety, report them to your healthcare provider or the local regulatory authority.

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