• Generic Name: Safinamide
  • Brand Name: Xadago
  • Dosage Forms: Oral tablets
  • Drug Class: Selective monoamine oxidase B (MAO-B) inhibitor


What is Xadago?

Xadago (safinamide) is a medication used in the treatment of Parkinson's disease. It belongs to the class of drugs known as selective monoamine oxidase B (MAO-B) inhibitors. Xadago works by inhibiting the enzyme MAO-B, which helps to increase the levels of dopamine, a neurotransmitter involved in movement control.

Indications and Uses:

Xadago is indicated as an adjunctive treatment to levodopa/carbidopa in patients with Parkinson's disease experiencing "off" episodes. "Off" episodes are characterized by a return of Parkinson's symptoms, such as tremors, stiffness, and difficulty with movement, due to a decrease in the effectiveness of levodopa therapy.

How Does Xadago Work?

The exact mechanism of action of Xadago in Parkinson's disease is not fully understood. However, it is believed to involve the selective and reversible inhibition of MAO-B enzyme activity. By inhibiting MAO-B, Xadago helps to prevent the breakdown of dopamine, thus increasing its availability in the brain. This can lead to improved motor function and a reduction in "off" episodes.

The Benefits of Xadago:

  • Reduction in "Off" Episodes: Xadago, when used as an adjunctive therapy with levodopa/carbidopa, has been shown to decrease the frequency and duration of "off" episodes in patients with Parkinson's disease. This results in improved motor function and increased quality of life.
  • Improved Motor Function: By increasing dopamine levels in the brain, Xadago helps to alleviate Parkinson's symptoms such as tremors, rigidity, and bradykinesia (slowness of movement). This can lead to improved motor function and enhanced mobility.
  • Extended Duration of Levodopa Effect: Xadago has been found to prolong the duration of the therapeutic effect of levodopa therapy. This means that the beneficial effects of levodopa can be sustained for longer periods, reducing the fluctuations in motor function commonly experienced by Parkinson's patients.

Warnings and Precautions:

  • Hypersensitivity: Inform your healthcare provider if you have any known allergies or sensitivities to safinamide or any other ingredients present in the medication.
  • Drug Interactions: Xadago may interact with other medications, including antidepressants and MAO inhibitors, and can cause serotonin syndrome. Inform your healthcare provider about all the medications you are taking to ensure the safe and effective use of Xadago.
  • Hypertension: Xadago has been associated with an increase in blood pressure. Regular monitoring of blood pressure is recommended during treatment with Xadago, especially in patients with a history of hypertension.
  • Hepatic Impairment: Xadago should be used with caution in patients with liver impairment. Dose adjustments may be necessary to ensure the safe and effective use of the medication.

Before Using Xadago:

  • Medical History: Discuss your complete medical history, including any past or present medical conditions, especially liver or kidney problems.
  • Pregnancy and Breastfeeding: The safety of Xadago in pregnant or breastfeeding women has not been established. Consult your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.
  • Other Medications: Inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter medications, and herbal supplements. This will help avoid potential drug interactions and ensure the safe use of Xadago.

Further Information:

  • Storage: Xadago should be stored at room temperature, away from moisture and heat. Follow the specific storage instructions provided by the manufacturer.
  • Disposal: Properly dispose of any unused or expired Xadago following local regulations or consult with your healthcare provider or pharmacist for guidance on safe disposal methods.
  • Accessibility: Xadago is available by prescription only and should be obtained from licensed healthcare facilities or pharmacies.
  • Reporting Adverse Effects: If you experience any adverse effects or have concerns about the medication's safety, report them to your healthcare provider or the local regulatory authority. Adverse effects can range from mild to severe and may vary from person to person. Reporting such effects helps monitor the safety and effectiveness of the medication and contributes to ongoing research and improvement of patient care.

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