Nexlizet: Why This Drug Helps In Lowering Your Cholesterol

Senior man taking pill at home

In the ever-evolving landscape of cardiovascular health, NEXLIZET emerges as a revolutionary force, offering a promising solution for adults grappling with the challenges of known cardiovascular disease. This once-daily, nonstatin pill is meticulously crafted to address the complexities of high cholesterol management. Let's understand the nuances of NEXLIZET and its profound impact on the cardiovascular system.

Understanding Bad Cholesterol

Bad cholesterol, scientifically known as low-density lipoprotein cholesterol (LDL-C), is a formidable adversary in cardiovascular health. Elevated levels of LDL-C contribute to atherosclerosis, a condition characterized by the accumulation of plaque in arteries, heightening the risk of heart attacks and strokes. NEXLIZET enters the scene as a strategic intervention, aiming to disrupt the vicious cycle of cholesterol-related complications.

High Systolic Blood Pressure

High systolic blood pressure, the top number in a blood pressure reading, is a significant cardiovascular risk factor. It occurs when the force of blood against artery walls is consistently too high, potentially leading to heart disease, stroke, and other complications. The coexistence of high cholesterol and increased systolic blood pressure amplifies cardiovascular risks, underscoring the importance of a holistic approach to managing these factors.


Medicine pills or capsules in hand

The mechanism of NEXLIZET brings a dual-action strategy orchestrated by its key component, bempedoic acid. Bempedoic acid, a cholesterol synthesis inhibitor, acts as a guardian by reducing the liver's production of cholesterol. This tandem approach lowers LDL-C, bringing a new targeted and effective cholesterol management.

Benefits and Uses of NEXLIZET

Cholesterol Reduction: NEXLIZET's distinctive ability to bind to bile acids in the intestine prevents reabsorption, resulting in increased excretion and a subsequent reduction in circulating cholesterol levels.

Lowering LDL Cholesterol: The hallmark of NEXLIZET's effectiveness lies in its targeted reduction of LDL cholesterol, commonly called "bad" cholesterol. This reduction is critical in mitigating the risk of atherosclerosis and associated cardiovascular diseases.

Adjunct to Diet and Lifestyle Changes: NEXLIZET is not a standalone solution but a crucial component in the treatment plan. It aligns seamlessly with dietary modifications, regular exercise, and weight management, forming a holistic approach to cholesterol treatment.

Reducing Cardiovascular Risk: By efficiently lowering LDL cholesterol levels, NEXLIZET emerges as a proactive measure in managing overall cardiovascular risk factors. This is particularly crucial in individuals with Heterozygous familial hypercholesterolemia and pre-existing cardiovascular conditions.

Treatment of Bile Duct Disorders: Beyond its primary role in cholesterol management, NEXLIZET showcases versatility by offering relief from itching associated with certain liver and bile duct disorders. Its ability to bind to bile acids plays a role in addressing symptoms beyond cholesterol reduction.

The Safety Landscape of NEXLIZET

NEXLIZET has effectively reduced LDL or low-density lipoprotein cholesterol levels through LDL treatment or lipid-lowering therapies. Still, like all medications, it comes with specific safety considerations. One of the notable concerns is the potential to reduce uric acid in the blood, which can lead to conditions such as gout. This is a serious consideration for individuals prone to or with a history of gout. Recognizing the signs of gout, including severe foot pain, warmth, swelling, tenderness, and redness in the joints, is crucial. If any of these symptoms manifest, it is imperative to consult with a healthcare professional promptly.

Tendon problems represent another severe side effect associated with NEXLIZET. Individuals taking the medication should be vigilant for signs of a tendon rupture, such as hearing or feeling a snap or pop in a tendon area, bruising right after an injury in a tendon area, or being unable to move the affected area or put weight on it. If any of these symptoms occur, discontinuation of NEXLIZET is recommended, and immediate medical attention is necessary.

Check This Out: Learn The Effective Heart Attack Treatment

Side Effects of NEXLIZET

Common Cold or Flu: Some individuals may experience symptoms resembling a common cold or flu, such as nasal congestion, sore throat, or mild respiratory discomfort. These symptoms are generally transient and do not pose significant health risks.

Muscle Spasms and Back Pain: Muscle-related side effects may occur, including spasms and back pain. These symptoms are usually manageable and tend to subside over time. However, persistent or severe discomfort should be promptly reported to healthcare providers.

Stomach Pain and Bronchitis: NEXLIZET may cause stomach pain; in some cases, individuals may experience bronchitis-like symptoms. These side effects are generally mild and temporary.

Increased Levels of Uric Acid: Elevated uric acid levels can lead to gout, a painful joint condition. Recognizing gout symptoms, such as severe foot pain, warmth, swelling, tenderness, and common redness, is crucial for prompt medical attention.

Tendon Problems: Serious tendon problems, including the risk of rupture, are a rare but severe side effect. If individuals experience a snap or pop in a tendon area, bruising after an injury in a tendon area, or an inability to move or put weight on the affected area, immediate medical assistance is warranted.

Other drugs showing results in cholesterol management

Pharmacist holding medicine box and capsule pack in pharmacy drugstore

The horizon of cholesterol drug management expands with the emergence of two groundbreaking drugs showing promise in targeting cholesterol at the genetic level. Although still in the research phase, these interventions provide a glimmer of hope for individuals with a genetic predisposition to high cholesterol, for whom traditional approaches prove insufficient.

VERVE-101: Precision Gene Editing

Originating from Verve Therapeutic, VERVE-101 introduces a paradigm shift by utilizing base editing through an intravenous route. Precision-targeting the PCSK9 gene associated with elevated LDL or low-density lipoprotein cholesterol, this treatment holds the potential for a one-time intervention with long-lasting effects. While the initial study involved a small participant pool, the safety results are promising, paving the way for further exploration.

Lepodisiran: Targeting Lipoprotein(a)

In another stride towards innovation, lepodisiran aims at lipoprotein(a), a protein intricately linked to clinical trial cholesterol. This therapy, backed by the financial support of Eli Lilly, showcases remarkable efficacy in reducing lipoprotein(a) levels by a staggering 94% with a single dose. This breakthrough provides hope for individuals with genetic conditions resistant to conventional interventions.

Research Implications and Cautionary Notes

While these advancements instill optimism, caution remains paramount. Extensive research is imperative before these genetic-level interventions transition from the laboratory to everyday practice. Rigorous assessments of safety, efficacy, and long-term impacts are prerequisites for regulatory approval. As Dr. Wesley Milks rightly points out, the journey from proof of concept to widespread acceptance involves subjecting these cholesterol therapies to ensure safety and effectiveness.

Also Read: Cholesterol Demystified: What You Need to Know Now


In cholesterol management, NEXLIZET raises hope for individuals struggling with high cholesterol and related conditions. Its multifaceted approach, complemented by ongoing research into genetic-level interventions, signifies a monumental stride toward personalized and clinical trial cholesterol management. As scientists learn more about how the heart works, new treatments will continue to emerge. This could enable people to safeguard their heart health actively.

© 2024 Copyrights - All Rights Reserved