Ustekinumab (Stelara) injecion

Generic name: ustekinumab [ YOO-sti-KIN-ue-mab ]

Brand name: Stelara
Dosage form: subcutaneous injection
Drug class: Interleukin inhibitors


Ustekinumab, known as Stelara, is a prime example of a breakthrough treatment for individuals with chronic autoimmune conditions. This injectable medication has transformed the management of various ailments, offering relief and improved quality of life for countless patients worldwide.

Introducing Ustekinumab (Stelara) Injection

Ustekinumab, marketed under the brand name Stelara, is a biological medication engineered to target specific proteins in the body that contribute to inflammation. By modulating the immune system's abnormal response, it effectively mitigates symptoms associated with autoimmune conditions. Unlike traditional treatments, which often provide temporary relief or carry significant side effects, Ustekinumab offers a promising alternative with lasting benefits.

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Five Uses of Ustekinumab (Stelara) Injection


Plaque psoriasis, characterized by raised, red patches of skin covered with silvery scales, affects millions worldwide. Ustekinumab has emerged as a game-changer in managing moderate to severe plaque psoriasis, significantly reducing symptoms and improving overall skin health.

Psoriatic Arthritis

Psoriatic arthritis, a form of inflammatory arthritis that affects individuals with psoriasis, can cause joint pain, stiffness, and swelling. Stelara is indicated for adults with active psoriatic arthritis, providing relief from joint symptoms and slowing disease progression.

Crohn's Disease

Crohn's disease, a chronic inflammatory condition of the gastrointestinal tract, poses significant challenges for patients due to its unpredictable nature. Ustekinumab is approved for the treatment of moderate to severe Crohn's disease in select patients, offering hope for symptom control and disease remission.

Ulcerative Colitis

Ulcerative colitis, a type of inflammatory bowel disease characterized by inflammation and ulcers in the colon and rectum, can significantly impact a patient's quality of life. Stelara is prescribed in some cases to manage symptoms of moderate to severe ulcerative colitis, providing relief from abdominal pain, diarrhea, and rectal bleeding.

Ankylosing Spondylitis

Ankylosing spondylitis is a chronic inflammatory arthritis primarily affecting the spine and sacroiliac joints. Stelara is approved for treating adults with active ankylosing spondylitis, improving mobility, and reducing pain associated with the condition.

Side Effects of Ustekinumab (Stelara) Injection

  1. Injection-site reactions: Pain, redness, or swelling at the injection site are common side effects of Ustekinumab injections.
  2. Upper respiratory infections: Patients may experience symptoms such as the common cold, sore throat, or sinus infections.
  3. Headache: Some individuals receiving Ustekinumab treatment report mild to moderate headaches.
  4. Fatigue: Feelings of tiredness or lethargy may occur, particularly during the initial stages of treatment.
  5. Nausea: Some patients may experience stomach discomfort or nausea following Ustekinumab injections.
  6. Back pain: Patients have reported pain or discomfort in the back area as a potential side effect.
  7. Dizziness: Some individuals may feel lightheaded or dizzy after receiving Ustekinumab injections.
  8. Allergic reactions: Although rare, severe allergic reactions may occur, including difficulty breathing and swelling of the face or throat.
  9. Infections: Ustekinumab may increase the risk of bacterial, viral, and fungal infections.
  10. Liver problems: Ustekinumab may cause liver-related side effects such as jaundice or abnormal liver function tests.

How to Administer Ustekinumab Syringe

  1. Prepare the Injection: Gather all necessary supplies, including the syringe, alcohol wipes, and a clean surface free from contamination.
  2. Choose the Injection Site: The abdomen or thighs are typically recommended for subcutaneous injections.
  3. Clean the Skin: Use an alcohol wipe to thoroughly clean the chosen injection site and allow it to dry completely.
  4. Prepare the Syringe: Remove it from its packaging and inspect it for any defects or damage.
  5. Inject the Medication: Follow your healthcare provider's instructions for proper injection technique to ensure accurate dosage administration.
  6. Dispose of the Syringe: To prevent accidental needlestick injuries, safely dispose of the used syringe in a designated sharps container.

Dosing Information of Ustekinumab (Stelara) Injection

For Crohns disease and ulcerative colitis, Stelara is administered as an infusion for the initial dose, followed by subcutaneous injections every eight weeks after that. In the case of psoriasis and psoriatic arthritis, Stelara is initially administered as a subcutaneous injection, followed by another dose four weeks later. Subsequently, injections are given every 12 weeks.

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Prior Preparations

Before receiving a Stekinumab (Stelara) injection, you must undergo a thorough evaluation and discuss any medical conditions or concerns with your healthcare provider. Ustekinumab may increase the risk of serious diseases. Certain cancers, including lymphoma, have been reported with the use of Ustekinumab.

Warnings for Ustekinumab (Stelara) Injection


Ustekinumab may increase the risk of serious illnesses, including tuberculosis, bacterial, viral, and fungal infections. Patients could have signs of disease and seek medical attention if symptoms develop.


Certain cancers, including lymphoma and skin cancers, have been reported using Ustekinumab. Patients should regularly monitor for signs and symptoms of malignancies during treatment.

Allergic Reactions

Serious allergic reactions, including anaphylaxis, may occur following  Ustekinumab injections. Patients should seek immediate medical attention if they experience difficulty breathing, swelling of the face or throat, or other signs of an allergic reaction.

Liver Problems

Ustekinumab may cause liver-related side effects, including abnormal liver function tests and jaundice. Monitoring of liver function is recommended during treatment.


Live vaccines should be avoided during treatment with Ustekinumab, as immunosuppression may reduce vaccine efficacy and increase the risk of vaccine-related complications.

Interactions with Ustekinumab (Stelara) Injection

  1. Immunosuppressive Medications: Concurrent use of other immunosuppressive medications may increase the risk of infections.
  2. Biologic Agents: Combining Ustekinumab with other biologic agents may increase the risk of adverse reactions, including infections and malignancies.
  3. Live Vaccines: Live vaccines should be avoided while treating Ustekinumab due to the risk of vaccine-related complications.
  4. Hepatotoxic Drugs: Certain medications that affect liver function may interact with Ustekinumab, necessitating careful monitoring.
  5. Alcohol: Excessive alcohol consumption may exacerbate liver-related side effects of Ustekinumab and should be avoided or limited during treatment.

Precautions for Ustekinumab (Stelara) Injection

Pregnancy and Breastfeeding

The safety of Ustekinumab during pregnancy and breastfeeding has not been established. Women of childbearing age should use effective contraception during treatment.

Children and Adolescents

The safety and efficacy of Ustekinumab in pediatric populations have yet to be adequately studied. Use in children and adolescents should be carefully considered based on individual circumstances.

Hepatic Impairment

The use of Ustekinumab should be approached with caution in patients with pre-existing liver conditions or impaired liver function.

Malignancy History

Patients with a history of malignancy should undergo careful evaluation and monitoring before initiating treatment with Ustekinumab.

Monitor for Infections

Patients receiving Ustekinumab look for signs of infection and promptly report any symptoms to their healthcare provider for evaluation and management.

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Ustekinumab (Stelara) injection represents a significant advancement in treating autoimmune conditions, offering relief and hope to countless individuals worldwide.  Open communication with your healthcare team is essential to address any concerns or questions you may have about your treatment regimen. With careful management and diligent monitoring, Ustekinumab promises to transform lives and empower individuals to regain control over their health and well-being.


How long does it take for Ustekinumab to work?

Response times may vary, but many patients experience symptom improvement within weeks to months of starting treatment. It's essential to continue treatment as prescribed and follow up with your healthcare provider regularly.

Can I self-administer Ustekinumab injections at home?

In some cases, patients may be trained to self-administer Ustekinumab injections at home under the guidance of their healthcare provider. Proper training and supervision are essential to ensure safety and efficacy.

What should I do if I miss a dose of Ustekinumab?

If you miss a scheduled dose of Ustekinumab, you can contact your guidance on the best course of action. To maintain treatment efficacy, it may be necessary to reschedule the missed dose or adjust the dosing schedule accordingly.

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